We are deriving rate equations and developing standard based approaches to measure enzyme kinetic parameters.
Welcome to the Schnell Lab
We develop methods and models to obtain high-quality measurements with rigor, reproducibility, and robustness in the biomedical sciences.
Our research program is strictly theoretical; we use mathematical, computational and statistical approaches in our work. We collaborate with several experimental research groups that provide us with data or collaborate with us to use models as tools for test hypothesis.
Latest NewsView all news
Sofia Medina, postbaccalaureate fellow, admitted to the University of Oxford
The matriculation in the math doctoral program is effective Sept. 2021.
Justin Eilertsen, postdoctoral fellow, appointed associate editor in Mathematical Reviews
The appointment is effective Aug. 9, 2021.
The appointment is effective Sept. 1, 2021.
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PeopleView all team
Recent CoversView all covers
Biophysical Chemistry 274, 106590.
The Journal of Physiology 597, 2317-2322.
Latest PublicationsView all publications
- M. A. Gingerich, X. Liu, B. Chai, G. L. Pearson, M. P. Vincent, T. Stromer, J. Zhu, V. Sidarala, A. Renberg, D. Sahu, D. J. Klionsky, S. Schnell, S. A. Soleimanpour (2021). The human disease gene CLEC16A regulates mitophagy. Autophagy, DOI: 10.1080/15548627.2022.2080383.
- J. Range, C. Halupczok, J. Lohmann, N. Swainston, C. Kettner, F. T. Bergmann, A. Weidemann, U. Wittig, S. Schnell, J. Pleiss (2022). EnzymeML - an exchange format for biocatalysis and enzymology. FEBS Journal, DOI: 10.1111/febs.16318.
- J. Eilertsen, S. Schnell (2022). On the validity of the stochastic quasi-steady-state approximation in open enzyme catalyzed reactions: Timescale separation or singular perturbation? Bulletin of Mathematical Biology, 84, 7.
- J. Eilertsen, M. A. Tyczynska, S. Schnell (2021). Hunting ε: The origin and validity of quasi-steady-state reductions in enzyme kinetics. SIAM Journal on Applied Dynamical Systems, 20, 2450-2481.
- N. D. Urban, J. P. Cavataio, Y. Berry, B. Vang, A. Maddali, R. J. Sukpraphrute, S. Schnell, M. Truttmann (2021). Explaining inter-lab variance in C. elegans N2 lifespan: Making a case for standardized reporting to enhance reproducibility. Experimental Gerontology, 156, 111622.
- J. C. Kasemeier-Kulesa, J. A. Spengler, C. E. Muolo, J. A. Morrison, T. E. Woolley, S. Schnell, P. M. Kulesa (2021). The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling. Developmental Biology 480, 78-90.
- D. Felker, H. Zhang, Z. Bo, M. Lau, Y. Morishima, S. Schnell, Y. Osawa (2021). Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry. Biophysical Chemistry 274, 106590. (cover article)
- W. Stroberg and S. Schnell (2021). Concentration sensing in crowded environments. Biophysical Journal 120, 1718-1731. code
- J. Eilertsen, M. R. Roussel, S. Schnell, S. Walcher (2021). On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism. AIMS Mathematics 6, 6781–6814.
- J. Cavataio and S. Schnell (2021). Interpreting SARS-CoV-2 fatality rate estimates: A case for introducing standardized reporting to improve communication. Mathematical Biosciences 333, 108545. (review)