Principles of Enzyme kinetics
We are deriving rate equations and developing standard based approaches to measure enzyme kinetic parameters.
Welcome to the Schnell Lab
We develop methods and models to obtain high-quality measurements with rigor, reproducibility, and robustness in the biomedical sciences.
Our research program is strictly theoretical; we use mathematical, computational and statistical approaches in our work. We collaborate with several experimental research groups that provide us with data or collaborate with us to use models as tools for test hypothesis.
Latest News
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People
Santiago Schnell elected Fellow of the Royal Society of Medicine
The Society was established in 1805 and has a long and rich history as a cross-specialty society sharing scientific, medical and healthcare knowledge.
People
Sofia Medina, postbaccalaureate fellow, admitted to the University of Oxford
The matriculation in the math doctoral program is effective Sept. 2021.
People
Santiago Schnell appointed dean of Notre Dame's College of Science
The appointment is effective Sept. 1, 2021.
Projects
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Standards for Reporting Enzymology Data.
We are developing Standards for Reporting Enzymology Data in collaboration with an international committee sponsored by the Beilstein-Institut.
EnzymeML
The EnzymeML language is an open standard based on the XML markup language.
People
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University of Notre Dame
USA -
University of Michigan
USA -
University of Pennsylvania
USA -
Medical University of Innsbruck
Austria
Recent Covers
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Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry
Biophysical Chemistry 274, 106590.
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Enhancing career development of postdoctoral trainees: Act locally and beyond
The Journal of Physiology 597, 2317-2322.
Latest Publications
View all publications- J. Eilertsen, S. Schnell, S. Walcher (2022). On the anti-quasi-steady-state conditions of enzyme kinetics. Mathematical Biosciences, DOI: 10.1016/j.mbs.2022.108870.
- J. Eilertsen, K. Srivastava, S. Schnell (2022). Stochastic enzyme kinetics and the quasi-steady-state reductions: Application of the slow scale linear noise approximation à la Fenichel. Journal of Mathematical Biology, DOI: 10.1007/s00285-022-01768-6. code
- M. A. Gingerich, X. Liu, B. Chai, G. L. Pearson, M. P. Vincent, T. Stromer, J. Zhu, V. Sidarala, A. Renberg, D. Sahu, D. J. Klionsky, S. Schnell, S. A. Soleimanpour (2022). The human disease gene CLEC16A regulates mitophagy. Autophagy, DOI: 10.1080/15548627.2022.2080383.
- J. Range, C. Halupczok, J. Lohmann, N. Swainston, C. Kettner, F. T. Bergmann, A. Weidemann, U. Wittig, S. Schnell, J. Pleiss (2022). EnzymeML - an exchange format for biocatalysis and enzymology. FEBS Journal, DOI: 10.1111/febs.16318.
- J. Eilertsen, S. Schnell (2022). On the validity of the stochastic quasi-steady-state approximation in open enzyme catalyzed reactions: Timescale separation or singular perturbation? Bulletin of Mathematical Biology, 84, 7.
- J. Eilertsen, M. A. Tyczynska, S. Schnell (2021). Hunting ε: The origin and validity of quasi-steady-state reductions in enzyme kinetics. SIAM Journal on Applied Dynamical Systems, 20, 2450-2481.
- N. D. Urban, J. P. Cavataio, Y. Berry, B. Vang, A. Maddali, R. J. Sukpraphrute, S. Schnell, M. Truttmann (2021). Explaining inter-lab variance in C. elegans N2 lifespan: Making a case for standardized reporting to enhance reproducibility. Experimental Gerontology, 156, 111622.
- J. C. Kasemeier-Kulesa, J. A. Spengler, C. E. Muolo, J. A. Morrison, T. E. Woolley, S. Schnell, P. M. Kulesa (2021). The embryonic trunk neural crest microenvironment regulates the plasticity and invasion of human neuroblastoma via TrkB signaling. Developmental Biology 480, 78-90.
- D. Felker, H. Zhang, Z. Bo, M. Lau, Y. Morishima, S. Schnell, Y. Osawa (2021). Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry. Biophysical Chemistry 274, 106590. (cover article)
- W. Stroberg and S. Schnell (2021). Concentration sensing in crowded environments. Biophysical Journal 120, 1718-1731. code
- J. Eilertsen, M. R. Roussel, S. Schnell, S. Walcher (2021). On the quasi-steady-state approximation in an open Michaelis-Menten reaction mechanism. AIMS Mathematics 6, 6781–6814.
- J. Cavataio and S. Schnell (2021). Interpreting SARS-CoV-2 fatality rate estimates: A case for introducing standardized reporting to improve communication. Mathematical Biosciences 333, 108545. (review)